Clofazimine-induced ichthyosis and its treatment.

Clofazimine is a valuable drug which is used worldwide in the treatment of leprosy. Unfortunately, patients often resist its use because ichthyosis is a frequent side effect. The use of 25 percent urea in an emollient lotion appears to relieve the ichthyosis and, consequently, encourages the continued use of this drug.

Treatment of trophic ulcers of leprosy with roniacol

1- A double-blind study of the use of Roniacol, a vasodilator, with respect to its effect on the healing time of plantar trophic ulcers, was made in four cases. 2- The drug is a harmless adjunct to other methods of therapy. 3- In some cases there may be benefit from its use, either subjectively or objectively, if collateral conditions of excessive fibrosis do not interfere with augmented circulation.